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Every part of the body has a nerve connection and not just one, but two. Stress depletes the adrenal glands of vital chemicals needed to maintain nerve transmission, resulting in decreasing mental and neurologic functioning including depression. Deficiencies in oxygen supply disables cells at best, killing them at worst.
Calcium and magnesium deficiencies can cause disruption of normal nerve transmission, resulting in anything from premenstrual irritability, and depression, to the irregular and potentially life-threatening heart rhythms.
